Aim:

The undesired movement of anchor teeth and relapse of previously moved teeth are major clinical problems in orthodontics. Angiostatin, a circulating inhibitor of angiogenesis, inhibits progression of osteolytic lesions. The aim of the study was to investigate the effects of different doses of angiostatin on bone-remodeling during orthodontic tooth movement due to determine the clinical utility in preventing undesired tooth movement and relapse.

Materials and Method:

To determine the effects of angiostatin in bone remodeling during experimental tooth movement, angiostatin was administered to rats at three different doses (Group 1, 2 and 3; 1, 3 and 10jjg/20jjl respectively). Mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. The results were evaluated histomorphometrically and parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were investigated at the interradicular bone area of the mandibular first molars.

Results:

In the comparison of Group 1 with Group 4 and 5, only the decrease in Tr.Sep was significant. The increase in BV/TV and the decrease in Tr.Sep were significant in the comparison of Group 2 against Group 4. In addition, the decrease in Tr.Sep was also statistically significant in Group 2, compared with Group 5. Increase in BV/TV and Tr.N, and decrease in Tr.Sep were significant in the comparison of Group 3 with Group 4. When Group 3 and Group 5 were compared, the increase in BV/TV and Tr.N, and the decrease in Tr.Sep were also statistically significant.

Conclusion:

Increases in BV/TV and Tr.N and decreases in Tr.Sep demonstrated the possibility of antiosteoclastic activity of angiostatin in bone remodeling during orthodontic tooth movement. The increase in dose caused an increase in bone apposition and/or inhibition of osteoclastic activity. Angiostatin inhibited the rate of resorption and further investigations with higher doses, different dose sequences and more detailed analyze programs were required to determine the specific effects on bone remodeling.

Keywords: Angiostatin, Antineoplastik agent, Angiogenesis inhibitor.