Timing of orthodontic treatments is a highly controversial subject in orthodontics. While some orthodontists advice intervention in early phases of the occlusal development, some suggest waiting for late mixed or early permanent dentition period. However, orthodontic treatments that may be carried out in early stage must be well known by all orthodontists due to the fact that the success in the treatment of some anomalies is related closely with the time the treatment starts. The aim of this review is to examine the treatment timing for different malocclusions and treatment approaches in the early stage.